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Autism Research
Current Research
Our research is
focused on delineation of the clinical and genetic
heterogeneity within the autism behavioral diagnosis and how this
information can be used to improve diagnosis, gene finding and treatment
for children with autism. One project, partly funded by a grant from the
National Association for Autism Research, has determined that the primary
step in the delineation of autism subgroups is to determine whether an
individual has essential or complex neurodevelopmental autism. About 30%
of individuals with autism have the complex phenotype, which is diagnosed
on the basis of a pattern of physical dysmorphology, indicating an
alteration in early morphogenesis. The remainder has essential autism that
is not associated with a recognizable insult to morphogenesis and occurs
with a higher male to female ratio and higher sib recurrence risk.
Additional research studies include investigations of the differences
between males and females with autism, the role of prenatal teratogen
exposures in the genesis of autism, and functional neuroimaging in autism
associated with macrocephaly.
Selected
Publications
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Miles JH,
Takahashi TN, Bagby S, Sahota PK, Wang CS, Farmer JE, Hillman RE. 2005.
Essential vs. Complex Autism: Definition of Fundamental Prognostic
Subtypes. Am J Med Genet 135A:171-180. [download PDF]
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Takahashi TN, Farmer JE, Deidrick
KK, Hsu BS, Miles JH, Maria BL. 2005. Joubert Syndrome is Not a Cause of
Classical Autism. Am J Med Genet 132A:347-351.
[download PDF]
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Stoelb M, Yarnal RK, Miles JH,
Takahashi TN, Farmer JE, McCathren RB. 2004. Predicting Responsiveness
to Treatment of Children with Autism: A Retrospective Study of the
Importance of Physical Dysmorphology, Focus on Autism & Other
Developmental Disabilities19:66-77. [download PDF]
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Miles JH, Takahashi TN, Hadden LL.
2003. Autism families with a high incidence of alcoholism. J Autism Dev
Disord 33(4):403-415. [download PDF]
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Miles JH, Hadden
LL, Takahashi TN, Hillman RE. 2000. Head circumference is an independent
clinical finding associated with autism. Am J Med Genet 95:339-350.
[download PDF]
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Miles JH, Hillman
RE. 2000. Value of a Clinical Morphology Examination in Autism. Am J Med
Genet 91:245-253. [download PDF]
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Hillman RE, Kanafani N, Bright JD,
Takahashi N, Miles JH. 2000. Changing prevalence of autism in Missouri:
Effect of a comprehensive state autism project. Missouri Medicine
97(5)159-163. [download PDF]
Other Projects
Autism Center
University of Missouri Health Care
Children's Hospital
One Hospital Drive
Columbia, MO 65212
573-884-1871 |